Centromere protein N (CENP-N)

Centromere protein N is a nuclear protein directly interacting with the histone variant CENP-A within centromeric chromatin, forming part of the core centromeric nucleosome complex that seeds kinetochore assembly. The N-terminal portion of CENP-N binds the CENP-A Targeting Domain (CATD) of CENP-A nucleosomes, stabilizing centromeric chromatin and contributing to the recognition of epigenetically defined centromeres. CENP-N, together with CENP-C, links centromeric chromatin with other centromere and kinetochore components, forming the basis for microtubule attachment required for faithful chromosome segregation during mitosis. Key insights: - CENP-N is not a therapeutic target but is a core structural protein necessary for chromosome stability in all dividing cells. - It acts primarily through specific protein-DNA and protein-protein interactions in the context of centromere and kinetochore complexes, notably the CCAN. - Defects or misregulation could contribute to disease such as cancer through chromosome instability. No known drugs, mechanisms of action for drug targeting, approved biomarkers, or direct safety concerns from clinical pharmacology are currently described for CENP-N. Disruption of normal function would likely be deleterious to cell viability and genome integrity.

Other names

CENPNC16orf60ICEN32BM-309FLJ13607FLJ22660BM039Interphase centromere complex protein 32