Centromere protein Q (CENPQ)

Centromere protein Q (CENPQ) is a component of the centromeric complex critical for targeting newly synthesized centromere protein A (CENPA) to centromeres and is required for proper kinetochore function and mitotic progression. It is part of the CENPO complex (including CENPO, CENPP, CENPQ, and CENPU) that acts in chromosome congression and the recruitment of specific kinetochore-associated proteins such as CENPE and PLK1. Mutations or dysregulation in CENPQ have been linked to rare hereditary disorders such as familial hyperinsulinemic hypoglycemia and may be associated with abnormal cell division and certain cancers, likely due to its role in chromosome stability and cell cycle progression. CENPQ is not conventionally classified as a "therapeutic target" such as a receptor, enzyme, ion channel, or transporter. There are currently no known drugs that directly target CENPQ, nor is it known to be used as a clinical biomarker or to present unique safety concerns in a therapeutic context. Research implicates CENPQ and related centromere proteins in cancer biology due to their overexpression and correlation with poor prognosis, especially in certain tumors; however, direct therapeutic targeting or established biomarker use is not documented.

Other names

CENPQCENP-QC6orf139FLJ10545