Centromere protein S (CENP-S)

Centromere protein S (CENP-S) is a DNA-binding protein that forms part of the constitutive centromere-associated network (CCAN) and is a component of a nucleosome-like complex at the centromere, including CENP-T, CENP-W, and CENP-X[1]. This complex is involved in the structural assembly and functional switching of the centromere during the cell cycle, converting centromeric chromatin into a mitosis-competent state after DNA replication. CENP-S participates in kinetochore assembly by acting as a chromatin receptor for mitotic machinery, and also has a role in the cellular response to DNA damage as a component of the Fanconi anemia (FA) repair pathway, where it is essential for activation of the FA pathway and maintenance of genomic stability[1][3]. Loss or dysfunction of CENP-S can lead to impaired chromosome segregation, genomic instability, and is relevant to cancer and Fanconi anemia pathogenesis. There are currently no drugs that specifically target CENP-S, and it is not employed as a clinical biomarker.

Other names

CENPSFAAP16MHF1APITD1Centromere protein SCENP-SFANCM-associated histone fold protein 1FANCM-interacting histone fold protein 1Fanconi anemia-associated polypeptide of 16 kDaApoptosis-inducing TAF9-like domain-containing protein 1

No known drugs directly target CENP-S; DNA repair modulation and chromosome segregation are general mechanisms in its pathway