Centromere protein S–cortistatin readthrough (CENPS-CORT)

CENPS-CORT readthrough represents a transcriptional fusion between the APITD1 gene (involved in apoptosis and cell cycle regulation, component of the Fanconi anemia complex and kinetochore assembly) and the CORT gene (cortistatin, a neuropeptide modulating neural and immune signaling). Alternative splicing of this locus yields fusion proteins with sequence identity to the products of both genes. The biological and clinical roles of the CENPS-CORT readthrough itself are poorly understood and largely unexplored; most functional knowledge pertains to the parent genes, with APITD1 implicated in cancer biology and mitotic regulation, and CORT in neuroendocrine signaling[1][2][6][9].\nThe official human gene nomenclature recognizes "CENPS-CORT readthrough" as a fusion transcript between two well-characterized genes. It is not a canonical protein target, receptor, or enzyme—thus most functional and disease-related insights should refer to APITD1 ("Centromere protein S") and CORT ("Cortistatin") individually, not their readthrough transcript[1][2][5][6][9].

Other names

APITD1-CORTAPITD1-CORT readthroughCENPS-CORT proteinApoptosis-inducing TAF9-like domain-containing protein 1Centromere protein S–cortistatin fusion

None established. No drugs act by targeting the readthrough product.