Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Centromere protein U (CENPU)
- Target
- CENPU
- Molecular classification
- Other (centromere/kinetochore-associated protein), Chromatin-associated protein
01
Overview
Centromere protein U (CENPU) is an essential, conserved centromere-associated factor required for the assembly and function of the kinetochore, a key structure for accurate chromosome segregation during mitosis[1][2][5]. CENPU functions within multiprotein centromere complexes, mediating kinetochore assembly, recruiting mitotic regulators (notably Polo-like kinase 1), directly interacting with core kinetochore components, and stabilizing kinetochore-microtubule attachment. It also plays a role in the spindle assembly checkpoint and may be involved in DNA double-strand break repair. Dysregulation or loss of CENPU leads to chromosome misalignment and segregation errors, contributing to conditions such as aneuploidy and has been implicated in cancer development[1][5].
- Other names
- CENP-UCENP-50PBIP1MLF1IPKLIP1ICEN24CENPU50KSHV latent nuclear antigen-interacting protein 1Interphase centromere complex protein 24polo-box-interacting protein 1
02
Mechanism of action
Not applicable—no known drugs directly target CENPU.
03
Biological functions
Centromere and kinetochore organizationChromosome segregation during mitosisSpindle assembly and checkpoint regulationRecruitment of mitotic regulators, especially Polo-like kinase 1 (Plk1)Microtubule binding and stabilization of kinetochore-microtubule attachmentsError correction in chromosome alignment (Aurora-B–mediated regulation)Possible role in DNA double-strand break repair
04
Disease associations
Cancer (e.g., reported association with cervical cancer)Aneuploidy (due to missegregation)Genomic instability/Other disorders linked to abnormal chromosome segregation
05
Safety considerations
No direct targeting drugs; however, alterations of this protein could potentially result in chromosome missegregation and aneuploidy, leading to genomic instability or cell death
06
Interacting drugs
None currently established as direct pharmacological agents targeting CENPU
07
Biomarkers
Changes in expression may serve as a biomarker for proliferative diseases such as cancer, but no validated or standardized clinical use
Beyond the preview
Go deeper on Centromere protein U (CENPU).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Centromere protein U (CENPU).