Centromere protein V (CENP-V)

Centromere protein V (CENP-V) is a centromere- and spindle-associated protein implicated in chromosome segregation and spindle formation during mitosis and meiosis[3][1][4]. CENP-V contains a C-terminal GFA-like enzymatic domain that can bind glutathione and is related to bacterial detoxifying enzymes[5][1]. It plays an essential architectural role for the primary constriction of mitotic chromosomes and stabilization of the chromosomal passenger complex (CPC); its proper levels are crucial for chromatin condensation and cell cycle progression[1][5]. Depletion of CENP-V results in major mitotic defects, including chromosome misalignment, altered chromatin states, and rapid cell death, highlighting its vital function for genomic stability[1][4][5]. No drugs directly target CENP-V and it is not classified as a therapeutic target, but its dysfunction is relevant for diseases linked to chromosome segregation defects (such as certain cancers and reproductive aging)[1][3].

Other names

PRR63110013H01Rikp30nuclear protein p30proline-rich protein 6