Centromere protein V-like protein 1 (CENPVL1)

Centromere protein V-like protein 1 (CENPVL1) is a protein coding gene listed on human genome databases, but is predicted rather than experimentally confirmed to encode a protein[7]. CENPVL1 is annotated to have potential carbon-sulfur lyase activity and metal ion binding activity, based on bioinformatic analysis rather than direct experimental evidence[7]. The gene is associated with several identifiers, including HGNC: 31851, NCBI Gene: 389857, Ensembl: ENSG00000223591, and previous symbols such as CENPVP1[7]. There is no evidence in the literature that CENPVL1 is a validated molecular target with a known role in cell signaling, regulation, or as a receptor/enzyme/ion channel/transporter. It is likely a pseudogene or a predicted locus, and not the same as Centromere protein V (CENP-V), which is a well-described component involved in chromosome segregation and spindle formation during mitosis and meiosis[1][5]. CENP-V itself is implicated in microtubule bundling and chromosome alignment, but there is no direct experimental data linking CENPVL1 to these processes[1][5][7]. Consequently, CENPVL1 is not considered a therapeutic target, it is not classified as a receptor, enzyme, transporter, or any other functional category, and has no described biological function, disease association, drug interaction, mechanism of action, biomarker role, or safety concerns in current scientific literature[7]. Furthermore, the abundance of analogous names and lack of experimental characterization suggests that this locus is likely incorrect as a drug target or suffers from misannotation and should be flagged for caution.

Other names

CENPVP1PRR6L1Centromere protein V pseudogene 1proline rich 6-like 1