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Target intelligence / Profile preview
Centromere protein W (CENPW)
- Target
- CENPW
- Molecular classification
- Other (centromere/kinetochore component), Kinetochore protein, Structural chromatin-associated protein
01
Overview
Centromere protein W (CENPW) is a structural component of the kinetochore complex at centromeres, the specialized chromosomal sites that are essential for correct chromosome segregation during mitosis and meiosis[2]. CENPW is a part of a subcomplex comprised of CENP-T and CENP-S/X/W, which together form a major interface for spindle microtubule attachment by organizing the outer kinetochore. Proper function of CENPW is crucial for the fidelity of chromosome segregation, and its deregulation or overexpression has been associated with increased cell proliferation and oncogenesis, as indicated by its alternative designation as "cancer up-regulated gene 2" in some databases[2]. There are no known approved therapeutics targeting CENPW directly, and it is not yet an established drug target, but its role in cancer and chromosomal instability suggests potential value for cancer research and as a prognostic biomarker.
- Other names
- CENPWC6orf173CUG2CENP-WCancer-up-regulated gene 2 proteincancer-upregulated gene 2
02
Biological functions
Chromosome segregation during cell divisionKinetochore assemblyMaintenance of proper chromosomal stability
03
Disease associations
Cancer
04
Safety considerations
Disruption can lead to chromosomal instability and aneuploidy, which are hallmarks of cancer, but no direct pharmacologic safety concerns are reported.
05
Biomarkers
Overexpression in certain cancer types (e.g., noted as "cancer-upregulated gene 2")
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