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Centrosomal protein 128 kDa (CEP128)
- Target
- CEP128
- Molecular classification
- Other (centrosomal protein; not a classic receptor, enzyme, transporter, or transcription factor)
01
Overview
Centrosomal protein 128 kDa (CEP128) is a structural protein localized at the subdistal appendages of centrioles, where it is essential for centrosome integrity, microtubule organization, and ciliary vesicle trafficking[1][3]. It plays a key regulatory role in transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) signaling, especially at the primary cilium, affecting cellular signaling and homeostasis[3]. CEP128 is necessary for proper spermatogenesis; mutations or loss of CEP128 cause severe male infertility in mice and are associated with sperm defects in humans[2][5]. Moreover, circular RNA isoforms from CEP128 (circ‑CEP128) act as competing endogenous RNAs, modulating microRNA pathways that influence cancer cell proliferation, migration, apoptosis, and chemoresistance[1]. There is no evidence that CEP128 is a therapeutic drug target or that it is directly modulated by existing drugs.
- Other names
- Centrosomal protein 128kDaC14orf145C14orf61LEDP/132lens epithelium-derived proteinCEP128
02
Biological functions
Centrosome organizationMicrotubule anchoringProtein localization (especially at centrioles and centrosome)Ciliary vesicle traffickingRegulation of TGF-β/BMP signalingSpermatogenesis
03
Disease associations
Male infertility (role in spermatogenesis disruption)Cancer (via regulatory circular RNA isoforms influencing tumor progression, apoptosis, and chemoresistance, such as in cervical cancer, bladder cancer, and glioma)
04
Biomarkers
circ‑CEP128 as a biomarker in certain cancers (cervical cancer, bladder cancer, glioma), especially regarding tumor progression and chemoresistance
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