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Target intelligence / Profile preview
Centrosomal protein 131 kDa (CEP131)
- Target
- CEP131
- Molecular classification
- Other (centrosomal protein, centriolar satellite component)
01
Overview
Centrosomal protein 131 kDa (CEP131) is a centriolar satellite-associated protein that localizes near the centrosome and plays crucial roles in centrosome homeostasis, centriole duplication, and primary cilia formation. CEP131 acts as an interactor and stabilizer of the Plk4/STIL complex, modulating the recruitment and stabilization of factors essential for the initiation of centrosome duplication. Loss or dysregulation of CEP131 affects the dynamics of microtubules, delays mitochondrial-dependent apoptosis, alters proteostasis, and is linked to genomic instability. Overexpression of CEP131 promotes centrosome amplification, genomic aberrations, and accelerates tumor formation, identifying it as a potential therapeutic target, particularly in oncology.
- Other names
- AZI1KIAA11185-azacytidine-induced protein 1Pre-acrosome localization protein 1AZ1ZA1
02
Biological functions
Centrosome homeostasisCentriole duplicationMicrotubule organizationAssembly of centriolar satellitesRegulation of primary cilia formationMitochondrial dynamicsRegulation of apoptosisClearance of aggresomesCell proliferationGenomic stability maintenance
03
Disease associations
Cancer (especially through centrosome amplification and genomic instability)Potential roles in apoptosis-related diseases and ciliary disorders
04
Safety considerations
Overexpression linked to centrosome amplification and cancerGenomic instability association
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