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Centrosomal protein 55 (CEP55)
- Target
- CEP55
- Molecular classification
- Other (centrosomal and midbody-associated protein), Microtubule-associated protein
01
Overview
Centrosomal protein 55 (CEP55) is a microtubule-associated protein that plays a critical role in the final stages of cytokinesis by controlling midbody structure and mediating successful cellular abscission[1][5]. CEP55 localizes to the centrosome during interphase and relocates to the midbody during cytokinesis, where it recruits ESCRT-III machinery necessary for daughter cell separation[3][5]. It acts as a scaffold, facilitating membrane fusion at the abscission site, and is regulated through phosphorylation events. Overexpression of CEP55 is linked to various cancers and it is recognized as a cancer/testis antigen, suggesting its value both as a biomarker and a potential therapeutic target, particularly in oncology[3][4][5].
- Other names
- Centrosomal protein of 55 kDaC10orf3URCC6FLJ10540CT111Up-regulated in colon cancer 6cancer/testis antigen 111MARCHcentrosomal protein 55kDa
02
Biological functions
CytokinesisMitotic exitCell divisionMembrane fusion/abscissionMicrotubule bundling
03
Disease associations
CancerChromosomal instabilityNeurodevelopmental disorder (microcephaly in mouse knockout)
04
Safety considerations
Potential chromosomal instability when dysregulatedAberrant cell division and cell death in neurodevelopmental context
05
Biomarkers
Marker for cancer-derived exosomesIncreased expression in multiple cancer types
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