Centrosomal protein 63 (CEP63)

Centrosomal protein 63 (CEP63) is a scaffold protein localized at the centrosome, the cell's main microtubule-organizing center[1][3]. It contains six coiled-coil domains and plays a central role in mother-centriole-dependent centriole duplication and spindle assembly, which are essential for proper cell division and genome stability[1][2][5]. CEP63 acts through direct interactions with other centrosomal proteins, notably CEP152, which together form a complex required for recruiting components necessary for procentriole formation and centriole-specific pathways[2][5]. Mutations in CEP63 are associated with human diseases including Seckel syndrome type 6 (a primary microcephaly disorder), myofibrillar myopathy 7, and have been implicated in certain cancers such as papillary thyroid cancer and colorectal cancer through promoting cell proliferation, migration, and survival[1][6][7]. CEP63 also participates in DNA damage response; its removal from centrosomes after DNA damage inactivates spindle assembly and leads to cell cycle delay[1]. There are currently no drugs reported to specifically target CEP63, nor established clinical biomarker or safety concerns linked to direct therapeutic targeting.

Other names

Centrosomal protein of 63 kDaCep63FLJ13386SCKL6Centrosome protein CEP63Centrosomal protein 63kDaCentrosome protein 63kDa