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Centrosomal protein of 152 kDa (CEP152)
- Target
- CEP152
- Molecular classification
- Other (Centrosomal structural protein)
01
Overview
Centrosomal protein of 152 kDa (CEP152) is a crucial structural component of the centrosome, acting as a molecular scaffold that facilitates interactions among core proteins (such as PLK4 and CPAP) necessary for centriole duplication and centrosome function. Essential for cell division, it assembles stepwise complexes that recruit kinases like CDK2 essential for centriole replication, thereby regulating the cell cycle. Mutations in CEP152 are linked to autosomal recessive microcephaly and Seckel syndrome, highlighting its central role in neural development and genomic stability[1][2][3][5].
- Other names
- CEP152KIAA0912SCKL5MCPH9MCPH4Centrosomal protein 152Centrosomal protein of 152 kDaAsterless (ortholog; Drosophila)
02
Biological functions
Centrosome duplicationCentriole replicationScaffold for protein interactions (notably PLK4 and CPAP)Key role in cell cycle regulation, particularly during mitosis
03
Disease associations
Microcephaly, primary autosomal recessive type 4 (MCPH4)Microcephaly 9, primary, autosomal recessive (MCPH9)Seckel syndrome 5
04
Safety considerations
Mutations can result in congenital disorders (e.g., microcephaly), indicating that excessive inhibition or loss-of-function could severely affect neurodevelopment
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