Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Centrosomal protein of 19 kDa (CEP19)
- Target
- CEP19
- Molecular classification
- Other (centrosomal protein)
01
Overview
Centrosomal protein of 19 kDa (CEP19) is a small, 167-amino acid protein that localizes to the distal end of the mother centriole within the centrosome and is critical for the initiation of primary cilia formation (ciliogenesis)[1][2]. CEP19 interacts with other centrosomal proteins—FOP (FGFR1OP) and CEP350—forming a regulatory module that is necessary for docking ciliary vesicles to centrioles and for early steps in cilium assembly[1][2]. Disruption of CEP19 function, including by a truncating R82* mutation, results in defective ciliogenesis and is associated with morbid obesity, indicating its likely involvement in ciliopathies[1][2]. There are no established roles for CEP19 as a direct target of drugs or as a biomarker in clinical applications at this time.
- Other names
- CEP19C3orf34HSD5MGC14126MOSPGFcentrosomal protein of 19 kDacentrosomal protein 19kDa
02
Biological functions
Ciliogenesis (formation of primary cilia)Microtubule anchoring at centrosome
03
Disease associations
Ciliopathies (defects can cause cilia-related disorders)Morbid obesity (R82* mutation associated with autosomal recessive morbid obesity in humans)Other
Beyond the preview
Go deeper on Centrosomal protein of 19 kDa (CEP19).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Centrosomal protein of 19 kDa (CEP19).