Centrosomal protein of 192 kDa (CEP192)

Centrosomal protein of 192 kDa (CEP192) is a conserved and essential scaffold protein localized at the centrosome in mammalian cells[1][2][5]. It orchestrates the recruitment and activation of key regulators required for centriole duplication, centrosome maturation, and spindle assembly, including the kinases Aurora A and PLK1 as well as proteins such as Plk4 and Cep152[2][3][5][8]. CEP192 serves as a platform for assembling pericentriolar material and thus controls centrosome size, microtubule nucleation, and spindle organization during mitosis, contributing to accurate chromosome segregation[1][2][3][4][5]. CEP192 dynamically interacts with kinases, including directly binding Aurora A, and is involved in the sequential activation of mitotic kinases essential for proper cell division[2][4][6][8]. Dysregulation or loss of CEP192 function leads to defects in centrosome integrity, spindle formation, and genomic instability, phenomena often implicated in tumorigenesis and cancer progression[2][3][5]. No direct interacting drugs or clinical biomarkers are currently established; however, its central role in mitotic spindle assembly makes it a potential emerging target in cancer therapy research[3][5]. Major safety concerns are related to centrosome amplification and defective chromosome segregation, contributing to aneuploidy if CEP192's function is perturbed[5].

Other names

Centrosomal protein 192KIAA1569PP8407Ce192/SPD-2PPP1R62protein phosphatase 1 regulatory subunit 62FLJ10352192 kDa centrosomal proteincentrosomal protein 192kDaSPD-2