Centrosomal protein of 68 kDa (CEP68)

Centrosomal protein of 68 kDa (CEP68) is a structural protein encoded by the CEP68 gene in humans. It localizes to the centrosome and plays a critical role in maintaining centrosome cohesion by forming, together with rootletin, an extended filamentous network that links centrioles and prevents their premature splitting during interphase and mitosis[1][2][3][6][7][11]. CEP68 contains a C-terminal spectrin repeat domain that mediates its structural interactions, particularly with rootletin, essential for assembling the centrosome cohesion apparatus[2]. CEP68 dissociates from centrosomes during mitosis, suggesting dynamic regulation of its function in the cell cycle[1]. Mutations and dysregulation of CEP68 are associated with rare inherited diseases such as retinitis pigmentosa 28 and angioedema[3]. Although it is vital for centrosome structure and function, CEP68 is not considered a canonical therapeutic target, with no drugs or clinical biomarkers linked to its modulation as of now[3][6][11].

Other names

CEP68KIAA0582Centrosomal protein 68kDaCentrosomal protein of 68 kDaCep68