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Centrosomal protein of 85 kDa (CEP85)
- Target
- CEP85
- Molecular classification
- Other (Centrosomal protein), Coiled-coil domain-containing protein
01
Overview
Centrosomal protein of 85 kDa (CEP85) is a coiled-coil domain-containing, centrosome-associated protein essential for efficient centriole duplication and cell cycle progression. It directly interacts with STIL to promote the early steps of centriole formation and modulates PLK4-driven cytoskeletal rearrangements and cell motility. Additionally, CEP85 acts as a negative regulator of the NEK2 kinase, maintaining centrosome integrity in non-dividing cells and suppressing centrosome disjunction. Mutations in CEP85 are linked to primary autosomal recessive microcephaly, highlighting its importance in neurodevelopment. There are currently no known drugs targeting CEP85, and it is not considered a therapeutic target in clinical practice.
- Other names
- CEP85CCDC21Cep85DKFZP434L0117Coiled-coil domain-containing protein 21Centrosomal protein 85kDa
02
Biological functions
Regulator of centriole duplication through direct interaction with STIL, a key factor in centriole formationModulator of PLK4-driven cytoskeletal rearrangements and cell motilityNegative regulator of NEK2 to maintain centrosome integrity during interphase; suppresses centrosome disjunction by inhibiting NEK2 kinase activityCell cycle progression (centrosome is a microtubule organizing center involved in cell-cycle progression)
03
Disease associations
Primary autosomal recessive microcephalyOther (no well-documented direct roles in cancer, inflammation, neurodegenerative disorders, cardiovascular disease, or infection)
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