Centrosome and spindle pole–associated protein 1 (CSPP1)

Centrosome and spindle pole–associated protein 1 (CSPP1) is a multifunctional microtubule-associated protein that localizes to centrosomes, spindle poles, kinetochores, and ciliary axonemes[1][3][4]. It is essential for cell cycle progression, spindle assembly, accurate chromosome segregation during mitosis, and cilia formation[1][4][5]. CSPP1 stabilizes microtubules by directly binding both their plus and minus ends, acting as a unique dual-end capping factor that preserves microtubule integrity, particularly in non-dividing and differentiated cells[2][3]. Mutations in CSPP1 lead to ciliopathies such as Joubert syndrome and may play roles in cancer biology, as aberrations in CSPP1 function are implicated in chromosomal instability and tumorigenesis[1][4][5]. CSPP1 is also considered a molecular marker for some subtypes of breast carcinoma[4]. Key details: - CSPP1 is not currently considered a direct therapeutic target or druggable protein; its primary significance is in disease biology and cell structure/cycle regulation, not as a receptor, enzyme, or transporter[1][5]. - Mutations are associated with severe developmental disorders, most notably Joubert syndrome, which feature ciliary defects[1][3][5]. - No drugs are currently known to interact directly with CSPP1, nor are there established mechanisms of drug action for this protein[5].

Other names

CSPPFLJ22490CSPP-LJBTS21centrosome and spindle pole–associated protein 1