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CEP295 N-terminal-like protein (CEP295NL)

Target: CEP295NL
Molecular classification: Other (no established classification as receptor, enzyme, channel, transporter, or transcription factor; predicted microtubule-associated)

Overview

CEP295 N-terminal-like protein (CEP295NL) is a predicted human protein that shares similarity to the N-terminal region of the centrosomal protein CEP295[1][3][4]. While CEP295 is well characterized and plays a key role in centriole biogenesis, centrosome assembly, cell cycle progression, and ciliogenesis[2][6], the exact biological function of CEP295NL remains largely uncharacterized and is inferred primarily from its sequence homology and predicted subcellular localization[3][4]. The protein is predicted to bind microtubules and participate in centriole biology, possibly contributing to centrosome or cilium function, but evidence of a clear pathological, mechanistic, or therapeutic role is lacking[3][4][7]. CEP295NL is located on chromosome 17 (17q25.1)[1] and is known by several alternative names including KIAA1731NL and DDC8[1][3][4][5][7]. There are no established drug interactions, known mechanisms of therapeutic action, or biomarker applications for this protein.

Other names: KIAA1731NLDDC8differential display clone 8protein DDC8 homologKIAA1731 N-terminal like protein

Biological functions

Predicted microtubule bindingPredicted regulation of centriole replicationPossible centrosome/centriole-related functions (by homology with CEP295)Likely cilium-related localization and function

Disease associations

Iminoglycinuria (only weak disease association from genetic variation databases; not well established)Other (no direct evidence for strong disease relevance)

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