Ceramide synthase 1 (CERS1)

Ceramide synthase 1 (CERS1) is an enzyme and transferase critically involved in sphingolipid biosynthesis, specifically the production of ceramides, with a preference for C18 acyl chains. It plays diverse roles in sphingolipid metabolism, ceramide biosynthesis, and the regulation of cell growth, differentiation, and apoptosis. CERS1 is also implicated in metabolic regulation and mitochondrial quality control. Its dysfunction or altered activity is linked to various disease states, including neurodegenerative diseases, cancer, metabolic diseases (such as insulin resistance and obesity), and epilepsy, making it a significant therapeutic target. Modulating CERS1 activity, for instance through inhibition, can reduce C18 ceramide levels, modulate mitochondrial fatty acid oxidation, and alter apoptosis sensitivity.

Other names

CerS1LAG1LASS1UOG1LAG1 longevity assurance homolog 1Longevity assurance gene 1 protein homolog 1Protein UOG-1Sphingoid base N-stearoyltransferase CERS1EPM8

Inhibition of ceramide synthesis (by CerS1 inhibition), Reduction of C18 ceramide levels, Modulation of mitochondrial fatty acid oxidation, Alteration of apoptosis sensitivity