Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cereblon E3 Ubiquitin Ligase Complex (CRL4^CRBN)
- Target
- CRL4^CRBN
- Molecular classification
- E3 Ubiquitin Ligase Complex, Enzyme Complex
01
Overview
The Cereblon E3 ubiquitin ligase complex is a multi-protein assembly that plays a central role in targeted protein degradation within cells. It is best known for its involvement in the ubiquitin-proteasome pathway, where it tags specific proteins with ubiquitin molecules, marking them for destruction by the proteasome. The core components include Cereblon (CRBN), DDB1, CUL4A/B, and ROC1/RBX1. CRBN acts as the substrate receptor, determining which proteins are selected for ubiquitination. This complex regulates diverse cellular processes and is targeted by drugs like thalidomide and its analogs, altering its substrate specificity. It is also an attractive component in PROTACs for targeted protein degradation therapies.
- Other names
- Cereblon complex
02
Mechanism of action
Modulation of substrate specificity leading to targeted protein degradation
03
Biological functions
Selective polyubiquitinationProtein degradationSignal transductionCell cycle progressionDNA damage responseEmbryonic developmentRegulation of gene expression
04
Disease associations
Multiple myelomaIntellectual disability syndromesNeurodevelopmental disorders
05
Safety considerations
Teratogenicity (thalidomide)Potential for off-target effects due to altered substrate specificity
06
Interacting drugs
Thalidomide
2 more in the full profile.
Beyond the preview
Go deeper on Cereblon E3 Ubiquitin Ligase Complex (CRL4^CRBN).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cereblon E3 Ubiquitin Ligase Complex (CRL4^CRBN).