Cereblon pseudogene

The "cereblon, pseudogene" (ENSG00000270516) refers to a genomic DNA sequence with high similarity to the functional CRBN gene but lacking the necessary capability to encode the cereblon protein. Pseudogenes are characterized by disruptions such as lack of promoters, premature stop codons, or frameshifts that prevent the production of a functional protein. These genetic elements are often remnants of gene duplications or retrotranspositions, and are generally considered nonfunctional in terms of protein expression. They do not share the therapeutic significance or disease relevance attributed to the true cereblon protein, which is encoded by the functional CRBN gene[1][2][3].

Other names

CRBN pseudogene