Cerebral endothelial cell adhesion molecule (CERCAM)

Cerebral endothelial cell adhesion molecule (CERCAM) is a probable cell adhesion protein expressed at the brain endothelium, where it is involved in mediating leukocyte transmigration across the blood-brain barrier. It is predicted to be located at the plasma membrane and is involved in cell-cell adhesion processes. Unlike many glycosyltransferases, CERCAM does not display enzymatic activity in vitro. Its expression and function are thought to contribute to immune cell entry into the CNS under physiological and pathological conditions. In cancer, upregulation or altered expression of CERCAM and other cell adhesion molecules in the brain may facilitate tumor cell adhesion, migration, and eventual brain metastasis, making it a potential, though not yet validated, therapeutic target in neuro-oncology and neuroimmunology[6][7][8][1].

Other names

Inactive glycosyltransferase 25 family member 3CEECAM1GLT25D3KIAA1502cerebral cell adhesion moleculeglycosyltransferase 25 domain containing 3cerebral endothelial cell adhesion molecule 1probable inactive glycosyltransferase 25 family member 3