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Cerebral Glucose Metabolism
- Molecular classification
- Metabolic Process, Physiological Process
01
Overview
Cerebral glucose metabolism encompasses all mechanisms by which the brain acquires and uses its principal fuel. It involves specialized transport systems at the BBB, intricate regulation matching supply with fluctuating demand across different regions/cell types, integration into biosynthetic pathways beyond mere energy provision—and its disruption underlies many acute/chronic neurological disorders.
02
Biological functions
ATP generationNeurotransmitter synthesisMaintenance of cellular functionRegulation of oxidative stressSynaptic transmissionIon gradient maintenance
03
Disease associations
Diabetes mellitusTraumatic Brain InjuryNeurodegenerative diseaseCognitive declineHypoglycemiaHyperglycemia
04
Safety considerations
HypoglycemiaHyperglycemiaImpaired cognitive functionNeurodegeneration
05
Biomarkers
CMRglc (Cerebral Metabolic Rate of Glucose)Blood glucose levelsCerebral Blood Flow (CBF)
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