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Cerebral tissue metabolism refers to the set of biochemical processes by which the brain acquires, utilizes, and transforms substrates (primarily glucose and oxygen) to generate the energy necessary for neural signaling, maintenance, and other cellular activities. The brain is highly dependent on a constant supply of glucose and oxygen due to its limited energy reserves and high metabolic demands. Disruptions in cerebral metabolism underlie numerous brain disorders, contribute to cognitive impairment in aging and disease, and are central in acute neurological events such as stroke. Although not a molecular drug target, cerebral metabolism can be measured and influenced indirectly, and abnormalities in this process serve as important biomarkers and pathophysiological features in many neurological conditions[1][2][3].
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