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Ceruloplasmin (CP)
- Target
- CP
- Molecular classification
- Glycoprotein, Multicopper oxidase, Enzyme
01
Overview
Ceruloplasmin is a blue, copper-containing glycoprotein primarily synthesized in the liver. It serves as the major copper-carrying protein in human blood and plays essential roles in both copper and iron metabolism. It functions as a multicopper oxidase (ferroxidase), catalyzing oxidation reactions involving iron (Fe²⁺ to Fe³⁺) and other substrates. It also plays an antioxidant role and is involved in iron metabolism by facilitating iron mobilization. Ceruloplasmin expression is regulated during inflammatory states and its levels are diagnostic markers for Wilson and Menkes diseases.
- Other names
- Ferroxidase IEC 1.16.3.1Copper oxidase
02
Mechanism of action
N/A
03
Biological functions
Copper transportFerroxidase activityAntioxidantIron metabolism
04
Disease associations
Wilson diseaseMenkes diseaseAceruloplasminemiaInflammationCancerNeurodegenerative diseaseMetabolic disorders
05
Safety considerations
Monitoring levels in patients with Wilson disease is essential to prevent copper toxicity.
06
Biomarkers
Low ceruloplasmin levels: Wilson disease, Menkes diseaseHigh ceruloplasmin levels: Inflammation, Cancer, Pregnancy
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