CFAP298-TCP10L readthrough (CFAP298-TCP10L)

The CFAP298-TCP10L readthrough is a fusion gene formed by the transcriptional continuation from the CFAP298 (C21orf59) gene into the adjacent TCP10L gene on chromosome 21. Readthrough transcripts may encode a fusion protein containing sequences from both parental gene products[2][8][9]. The precise biological function and disease relevance of the fusion protein remain unknown; it is not currently considered a drug target or biologically characterized protein. The parent genes are involved in ciliary function and assembly, with associated diseases including primary ciliary dyskinesia and heterotaxy, but evidence for involvement of the fusion gene in these conditions is lacking[2][3]. Alternative gene symbols and names reflect its hybrid nature and include those of both parental genes and long intergenic non-coding RNAs[2][8][9]. Existing protein databases annotate it as a protein coding locus, but further experimental validation and functional characterization are needed.

Other names

CFAP298-TCP10LC21orf59-TCP10LLINC00846C21orf77FLJ10932Long intergenic non-protein coding RNA 846Uncharacterized protein LOC110091775