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Target intelligence / Profile preview
CFAP44 antisense RNA 1 (CFAP44-AS1)
- Target
- CFAP44-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Other
01
Overview
CFAP44 antisense RNA 1 (CFAP44-AS1), also known as WDR52-AS1, is a long non-coding RNA (lncRNA) expressed primarily in the testis and plays a regulatory role in the expression of the nearby CFAP44 gene, which encodes a protein essential for the formation and function of flagella and cilia in sperm[1][2][3][4][6][7]. Expression of CFAP44-AS1 is positively correlated with sperm motility and normal morphology; reduced levels are observed in men with infertility characterized by asthenozoospermia (reduced sperm motility) and terato-asthenozoospermia (abnormal sperm shape)[1][2][4]. Its deregulation is considered an important factor that may contribute to male infertility, suggesting a specialized role in reproductive biology rather than as a classic therapeutic target[1][2][4]. There is currently no evidence for targeting CFAP44-AS1 with drugs, and it is not classified as a receptor, enzyme, transporter, or similar therapeutic target.
- Other names
- WDR52-AS1WDR52 antisense RNA 1 (non-protein coding)CFAP44-AS1
02
Biological functions
Regulation of gene expressionSpermatogenesisMaintenance of sperm motility and morphology
03
Disease associations
Male infertilityAsthenozoospermiaTerato-asthenozoospermia
04
Biomarkers
Expression level may serve as a biomarker for sperm motility/morphology and male infertility
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