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Target intelligence / Profile preview
cGMP-dependent protein kinase I alpha (None)
- Target
- None
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
cGMP-dependent protein kinase I alpha (PKG Iα) is a serine/threonine protein kinase that serves as a key mediator of the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway. It plays central roles in multiple physiological processes including relaxation of vascular and gastrointestinal smooth muscle, inhibition of platelet aggregation, modulation of cardiac hypertrophy, and neuroprotection. Recent research also implicates nociceptor-localized PKGI as critical for central sensitization underlying neuropathic pain states.
- Other names
- PKGIαPRKG1 alpha
02
Mechanism of action
Phosphorylation of target proteins upon cGMP binding
03
Biological functions
Signal transductionSmooth muscle relaxationPlatelet inhibitionNeuroprotectionCardiac protectionSynaptic plasticity
04
Disease associations
Cardiovascular diseaseNeuropathic painNeurodegenerative disease
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