Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
cGMP-specific phosphodiesterase type 5 (PDE5)
- Target
- PDE5
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
cGMP-specific phosphodiesterase type 5 (PDE5) is an enzyme that hydrolyzes cyclic guanosine monophosphate (cGMP) to its inactive form, 5’-GMP, thereby regulating intracellular levels of cGMP. It plays a central role in the control of smooth muscle contraction and relaxation by modulating the cGMP signaling pathway. PDE5 is a major drug target due to its tissue distribution and physiological importance, with inhibitors like sildenafil and tadalafil being used to treat erectile dysfunction and pulmonary arterial hypertension.
- Other names
- Cyclic guanosine monophosphate-specific phosphodiesterase type 5PDE 5A
02
Mechanism of action
Competitive inhibition of PDE5 catalytic site.
03
Biological functions
Regulation of smooth muscle contractionRegulation of vascular tonePlatelet aggregationCardiac function modulationNeurotransmissionCalcium homeostasisRetinal phototransduction
04
Disease associations
Erectile dysfunction (ED)Pulmonary arterial hypertension (PAH)Cardiac hypertrophyHeart failureCancer
05
Interacting drugs
Sildenafil
3 more in the full profile.
Beyond the preview
Go deeper on cGMP-specific phosphodiesterase type 5 (PDE5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on cGMP-specific phosphodiesterase type 5 (PDE5).