ChaC glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2)

ChaC glutathione-specific gamma-glutamylcyclotransferase 2 (abbreviated CHAC2) is an enzyme that catalyzes the cleavage of glutathione (GSH) into 5-oxo-L-proline and cysteinyl-glycine, acting specifically on glutathione but not other gamma-glutamyl peptides[3][5]. CHAC2 is a cytosolic enzyme involved in maintaining glutathione homeostasis and is upregulated in response to endoplasmic reticulum stress, enhancing apoptotic pathways via glutathione depletion[1][3]. Structural studies identify CHAC2 as having a unique flexible loop involved in GSH specificity and enzymatic regulation[1]. Overexpression of CHAC2 has been linked to enhanced proliferation of cancer cells, and it may play a role in the progression of glutathione-related diseases such as cancer and glutathionuria[1][3][5]. The molecule is being investigated as a potential therapeutic target, particularly for diseases where manipulation of glutathione metabolism might be beneficial[1].

Other names

CHAC2ChaC2Gamma-glutamylcyclotransferase 2