Chaperonin containing TCP1 subunit 6A (CCT6A)

Chaperonin containing TCP1 subunit 6A (CCT6A) is the zeta subunit of the eukaryotic chaperonin TRiC/CCT complex, a large double-ring oligomeric molecular chaperone residing in the cytosol. This complex assists in the ATP-dependent folding of critical cytoskeletal proteins, mainly actin and tubulin, and other client proteins including components of mTOR signaling. CCT6A plays a role in protein homeostasis, cell cycle control, and has been implicated in cancer progression, with high expression linked to poor prognosis in breast and colorectal cancer. Overexpression may serve as a biomarker, and surface localization in some cells enables antigenic recognition in immune responses. While not yet a direct drug target, CCT6A is considered a potential therapeutic target for oncology and autoimmune applications.

Other names

T-complex protein 1 subunit zetaCCT6CCTZTCP-1-zetaTTCP20TCPZHTR3TCP20Acute morphine dependence-related protein 2CCT-zeta-1MoDP-2amino acid transport defect-complementinghistidine transport regulator 3CctzCCT-zeta

As a chaperonin, any drug targeting CCT6A or the TRiC complex would primarily influence protein folding homeostasis; in cancer, targeting this protein may disrupt cytoskeletal protein folding, cell cycle progression, and mTOR signaling.