Charged multivesicular body protein 2A (CHMP2A)

Charged multivesicular body protein 2A (CHMP2A) is a core component of the ESCRT-III complex, a multiprotein machinery that enables the formation and maturation of multivesicular bodies (MVBs)—endosomal compartments critical for degrading membrane proteins, sorting cellular cargo, and facilitating receptor downregulation[1][5]. CHMP2A specifically is required for membrane fission processes such as phagophore closure during autophagy, cytokinesis, and nuclear envelope reformation[1][2]. It plays a significant role in regulating autophagic flux and is fundamental to proper lysosomal turnover, with depletion leading to the accumulation of immature autophagosomal structures[2]. Additional evidence links CHMP2A with HIV-1 virus budding, cancer (as a breast adenocarcinoma marker), and neurodegenerative disease. It is regarded as a relevant molecular target for investigating vesicular trafficking, autophagy, and cellular homeostasis[1][2][5].

Other names

Charged multivesicular body protein 2aCHMP2ABC2CHMP2CHMP2aVps2-1hVps2-1BC-2VPS2VPS2AChromatin-modifying protein 2aPutative breast adenocarcinoma marker BC-2Vacuolar protein sorting-associated protein 2-1VPS2 homolog A (S. cerevisiae)charged multivesicular body protein 2aVPS2 homolog Achromatin modifying protein 2Aputative breast adenocarcinoma marker (32kD)