Charged multivesicular body protein 2B (CHMP2B)

Charged multivesicular body protein 2B (CHMP2B) is a core subunit of the ESCRT-III membrane trafficking complex, essential for the biogenesis and sorting of multivesicular endosomes (MVBs) and for autophagy, membrane repair, and several other events involving membrane remodeling[2][6]. CHMP2B is found in neurons and other cells; it recruits the AAA-ATPase Vps4 to mediate membrane scission and ESCRT-III disassembly[2][1][6]. Mutations affecting the C-terminal auto-inhibitory domain or Vps4-interacting motifs disrupt normal endolysosomal and autophagosomal clearance, causing accumulation of protein aggregates and abnormal neuronal morphology, and are associated with autosomal-dominant frontotemporal dementia (FTD3) and familial ALS7 (FTDALS7)[1][3][5][6]. No approved drugs directly target CHMP2B; it is studied for its pathophysiological impact and as a biomarker in neurodegenerative disease models.

Other names

Charged multivesicular body protein 2bCGI-84CHMP2bVps2-2hVps2-2DKFZP564O123CHMP2.5VPS2BChromatin-modifying protein 2bVacuolar protein sorting-associated protein 2-2VPS2 homolog B (S. cerevisiae)ALS17DMT1FTDALS7VPS2-2chromatin modifying protein 2B