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CHD1 helical C-terminal domain containing protein 1 (CHCT1)
- Target
- CHCT1
- Molecular classification
- Other (contains a CHD1 helical C-terminal domain, but not itself a chromatin remodeler, enzyme, receptor, etc.)
01
Overview
CHD1 helical C-terminal domain containing protein 1 (CHCT1; previously designated as C17orf64) is a poorly characterized human protein notable for containing the CHD1 helical C-terminal (CHCT) domain—a structural motif of five α-helices first described in the chromatin remodeler CHD1, where it mediates DNA and nucleosome binding. This domain has been identified in the C17orf64 protein family, although the cellular function, disease associations, and potential as a therapeutic target for CHCT1 remain unstudied and are not established in the literature. The functional role of CHCT1 may relate to chromatin or DNA interactions by analogy to CHD1, but this is speculative. No drugs, disease roles, or validated biomarkers are reported for CHCT1.
- Other names
- CHCT1C17orf64CHD1 helical C-terminal domain containing 1Uncharacterized protein C17orf64
02
Biological functions
Likely binds DNA and/or nucleosomes (inferred from domain structure, evidence in C17orf64 is not established)Unknown/other (no direct functional validation in humans)
03
Disease associations
Other/unknown (no disease association described in the literature)(CHD1, with a homologous domain, is involved in cancer, particularly prostate cancer, but this is not established for C17orf64/CHCT1)
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