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CHD2 adjacent suppressive regulatory RNA
- Molecular classification
- Long noncoding RNA
01
Overview
CHASERR is a long noncoding RNA (lncRNA) located adjacent to the CHD2 gene on chromosome 15. It functions as a cis-acting transcriptional repressor of CHD2, regulating its expression and maintaining proper chromatin remodeling activity. Deletions or haploinsufficiency of CHASERR are associated with a distinct syndromic neurodevelopmental disorder characterized by severe developmental delay, early-onset encephalopathy, facial dysmorphisms, and cerebral hypomyelination/cortical atrophy.
- Other names
- LINC01578
02
Mechanism of action
Cis-acting transcriptional repressor of CHD2
03
Biological functions
Transcriptional repressionRegulation of gene expressionChromatin remodeling regulationAdipose tissue developmentThymus development
04
Disease associations
Neurodevelopmental disordersEncephalopathyCerebral hypomyelinationCortical atrophy
05
Safety considerations
Upregulation of CHD2 may lead to transcriptional interference with downstream promoters
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