Chediak-Higashi syndrome 1 pseudogene

The **Chediak-Higashi syndrome 1 pseudogene** (ENSG00000235775) is a non-functional pseudogene related by sequence homology to the *LYST* gene, which encodes the lysosomal trafficking regulator protein. Chediak-Higashi syndrome (CHS) itself is a rare, autosomal recessive disorder caused by loss-of-function mutations in *LYST*, leading to defects in lysosome trafficking, oculocutaneous albinism, immune deficiency, and neurological dysfunction. The CHS1 pseudogene does not produce a functional protein and does not have known biological or clinical significance[1][7].\n\nKey clarification: \n- The biologically and clinically relevant gene in Chediak-Higashi syndrome is *LYST*, usually referred to as "lysosomal trafficking regulator". The pseudogene has no known role in disease mechanisms or diagnostics and is not a molecular target for therapy[1][7]. \n- If you are seeking information relevant to the disease or therapeutic intervention, you should refer to the functional *LYST* gene, not its pseudogene.\n\nIf "target" information is sought for drug discovery, *LYST* is the correct entity; this entry (ENSG00000235775) does not correspond to a molecular target.

Other names

CHS1 pseudogeneCHS1P