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Target intelligence / Profile preview
Chemokine (C-C motif) ligand 21 (CCL21)
- Target
- CCL21
- Molecular classification
- CC Chemokine, Cytokine, Ligand
01
Overview
Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. It primarily functions as a homeostatic chemokine involved in immune cell trafficking, guiding CCR7-expressing leukocytes—such as naïve T cells and dendritic cells—to secondary lymphoid organs. CCL21 is essential for accumulation of developing thymocytes and critical for central self-tolerance establishment among T cells. It is constitutively produced in secondary lymphoid organs and expression increases during inflammation. CCL21 interacts with the receptor CCR7 triggering signaling pathways leading to cellular responses including migration/chemotaxis.
- Other names
- 6Ckineexodus-2secondary lymphoid-tissue chemokineSLC
02
Mechanism of action
N/A
03
Biological functions
Immune cell guidanceT cell homingDendritic cell migrationChemotaxisThymic developmentCentral tolerance induction
04
Disease associations
InflammationRheumatoid arthritisSjögren’s syndromeUlcerative colitisCrohn’s diseaseAutoimmunity
05
Safety considerations
Overexpression linked with chronic inflammatory diseases due to its role in recruiting immune cells into inflamed tissues where it may drive formation of tertiary/ectopic lymphoid structures.
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