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Target intelligence / Profile preview
Chemokine (C-X-C motif) ligand 10 (CXCL10)
- Target
- CXCL10
- Molecular classification
- Chemokine, Cytokine, Secreted protein
01
Overview
CXCL10 is an inflammatory chemokine secreted by various cell types in response to interferon-gamma (IFN-γ). It plays a crucial role in recruiting and activating immune cells, particularly T cells, to sites of inflammation or infection. Its primary receptor is CXCR3, and its signaling leads to a variety of cellular responses, including cell migration, apoptosis, and angiogenesis inhibition. CXCL10 is implicated in numerous diseases, including viral infections, autoimmune disorders, and cancer, making it a potential therapeutic target.
- Other names
- Interferon gamma-induced protein 10IP-10small-inducible cytokine B10
02
Mechanism of action
Binding to CXCR3 activates G-protein-mediated signaling pathways, leading to downstream effects like phospholipase C activation, increased intracellular calcium, actin cytoskeleton reorganization, and cell migration/activation/differentiation/apoptosis.
03
Biological functions
ChemoattractionT cell adhesionApoptosis inductionAngiostasisImmune responseInflammation
04
Disease associations
Viral infectionsCancerAutoimmune diseasesMultiple sclerosis (MS)Hepatitis C-associated endotheliitisSpinal cord injuryInflammation
05
Safety considerations
Potential for off-target effects due to promiscuity with other chemokine receptors (e.g., CCR3)Possible development of resistance to CXCL10-targeting therapiesUnintended consequences of broad immune modulation
06
Biomarkers
CXCL10 levels in serum/tissue as a marker of inflammationCXCL10 levels as a predictor of response to therapy in certain diseases (e.g., viral infections)
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