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Target intelligence / Profile preview
Chemokine C-X-C motif ligand 9 (MIG)
- Target
- MIG
- Molecular classification
- Chemokine, CXC chemokine
01
Overview
CXCL9, also known as monokine induced by gamma interferon (MIG), is a small cytokine belonging to the CXC chemokine family. It is primarily induced by interferon-gamma (IFN-γ) and plays a key role in immune cell recruitment and activation, especially during inflammatory responses. Its interaction with CXCR3 regulates migration, differentiation, and activation of immune cells. CXCL9 can have both pro- and anti-tumor effects depending on the cancer context.
- Other names
- CXCL9Monokine induced by gamma interferon
02
Mechanism of action
CXCL9 interacts with its receptor CXCR3 to regulate migration, differentiation, and activation of immune cells.
03
Biological functions
ChemotaxisLeukocyte proliferationLeukocyte differentiationTissue extravasationImmune cell recruitmentImmune cell activation
04
Disease associations
CancerInflammation
05
Safety considerations
Context-dependent pro-/anti-tumoral effects in cancer.
06
Biomarkers
CXCL9 expression levels correlate with infiltration/activation status of effector immune populations such as CD8+ T-cells.
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