Chemokine C-X-C motif receptor 1 (CXCR1)

Chemokine C-X-C motif receptor 1 (CXCR1) is a G protein-coupled receptor principally expressed on neutrophils and other immune cells, serving as a high-affinity receptor for the chemokine CXCL8 (also known as interleukin-8)[2][3]. Activation of CXCR1 by CXCL8 initiates intracellular signaling that promotes chemotaxis, degranulation, and other neutrophil effector functions crucial for innate immune response and inflammation[2]. CXCR1, along with the closely related CXCR2, is implicated in mediating inflammatory responses and plays a notable role in several pathological conditions, including cancer progression, infections, and chronic inflammatory diseases[2]. The receptor is a validated therapeutic target with several inhibitors studied for inflammatory and oncologic indications, though its central role in neutrophil function raises potential safety concerns regarding infection susceptibility[2][3].

Other names

Interleukin-8 receptor AIL-8RACD181C-X-C chemokine receptor type 1

Antagonism of receptor-mediated chemokine signaling; Blockage of G protein signaling cascade; Inhibition of neutrophil migration and activation