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Target intelligence / Profile preview
Chemokine ligand 21 receptor (CCR7)
- Target
- CCR7
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
CCR7 (C-C chemokine receptor type 7), also known as CD197, is a G protein-coupled receptor (GPCR) that binds to the chemokines CCL19 and CCL21. It plays a crucial role in immune cell trafficking to secondary lymphoid organs and is involved in both anti-tumor immunity and cancer metastasis. Due to its complex roles, therapeutic targeting of CCR7 requires careful consideration of the specific disease context.
- Other names
- C-C chemokine receptor type 7CD197
02
Mechanism of action
Agonism or antagonism of CCR7 signaling (context-dependent)
03
Biological functions
Immune cell traffickingCell migrationSignal transductionRegulation of actin dynamicsImmune response
04
Disease associations
Cancer metastasisCancer progressionChronic inflammationRheumatoid arthritis
05
Safety considerations
Dual role in cancer (promoting anti-tumor immunity vs. metastasis)Potential for off-target effects due to widespread expression in immune cells
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