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Target intelligence / Profile preview
Chemokine-like protein TAFA-3 (TAFA3)
- Target
- TAFA3
- Molecular classification
- Secreted protein, Chemokine-like protein, Other
01
Overview
Chemokine-like protein TAFA-3 (TAFA3, FAM19A3) is a small secreted protein, distantly related to the CC-chemokine family, and is part of the TAFA/FAM19A family. It is predominantly expressed in specific brain regions and is proposed to function as a brain-specific chemokine or neurokine, acting as a regulator of immune and nervous cells. TAFA-3 is involved in the regulation of microglia polarization and neuroblast differentiation, linking it to essential neuroimmune and developmental processes. Disruption in TAFA3 function in animal models results in altered social behavior, impaired communication, and increased repetitive behaviors, suggesting a key role in brain physiology and possibly in neuropsychiatric diseases[1][2][5][6][8].
- Other names
- TAFA3FAM19A3TAFA-3chemokine-like protein TAFA-3family with sequence similarity 19 member A3C-C motif chemokine-likeprotein FAM19A3
02
Biological functions
Regulation of microglial cell activationNeuroblast differentiationRegulation of microglia polarizationRegulation of immune cellsNervous system cell regulation
03
Disease associations
Neurodegenerative diseaseNeurological diseaseInflammationOther (based on animal phenotypes)
04
Safety considerations
Potential for neurological effects based on knockout mouse models (social behavior, communication deficits, repetitive behaviors)
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