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Chemokine-Mediated Metastatic Process
- Molecular classification
- Signaling pathway, Chemokine signaling network
01
Overview
The chemokine-mediated metastatic process describes the role of chemokines and their receptors in facilitating cancer cell dissemination and metastasis. It involves multiple steps, including pre-metastatic niche formation, recruitment of immune and stromal cells, induction of EMT, and direct promotion of tumor cell migration and invasion. Several chemokine/receptor pairs, such as CXCL8/CXCR1, CCL2/CCR2, and CXCR4/CXCL12, are implicated in this process, and targeting these pathways is under investigation as an anti-metastatic therapeutic strategy.
- Other names
- Chemokine signaling in metastasisChemokine-driven cancer metastasisMetastasis via chemokine pathways
02
Mechanism of action
Varies depending on the specific chemokine/receptor axis targeted, including receptor blockade, inhibition of downstream signaling pathways (e.g., PI3K/Akt, MAPK), and disruption of immune cell recruitment.
03
Biological functions
Cell migrationCell invasionAngiogenesisImmune modulationPre-metastatic niche formationEpithelial-mesenchymal transition (EMT)
04
Disease associations
Cancer metastasisTumor progression
05
Safety considerations
Potential for off-target effects on immune cell trafficking and functionDevelopment of resistance to chemokine-targeted therapiesContext-dependent effects of chemokines (some may have anti-tumor roles)
06
Interacting drugs
CXCR4 inhibitors
2 more in the full profile.
07
Biomarkers
CXCL8 expressionCXCR1 expressionCCL2 expressionCCR2 expressionCXCR4 expressionCXCL12 expression
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