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Target intelligence / Profile preview
Chemokine receptor 8 (CCR8)
- Target
- CCR8
- Molecular classification
- G protein-coupled receptor, Seven-transmembrane receptor, GPCR, Chemokine receptor
01
Overview
Chemokine receptor 8 (CCR8) is a class A G protein-coupled receptor that binds to chemokines such as CCL1 and CCL8. It plays a role in monocyte chemotaxis, thymic cell apoptosis, and T cell positioning. CCR8 is highly expressed on tumor-infiltrating regulatory T cells (Tregs) and facilitates their recruitment to tumors, contributing to immunosuppression. It is a therapeutic target for cancer immunotherapy and autoimmune diseases.
- Other names
- CC-CKR-8CCR-8CDw198CKRL1CMKBR8CMKBRL2CY6GPRCY6TER1
02
Mechanism of action
Agonist or antagonist binding to CCR8 modulates downstream signaling pathways, affecting immune cell migration and function, particularly that of Tregs.
03
Biological functions
Monocyte chemotaxisThymic cell apoptosisT cell positioningImmune cell recruitmentRegulation of immune responses
04
Disease associations
CancerAutoimmune diseasesHIV-1 infection
05
Safety considerations
Potential for off-target effects on peripheral tolerance mechanisms if CCR8 targeting is not specific to tumor microenvironment.Potential for immune-related adverse events.
06
Interacting drugs
LMD-009
1 more in the full profile.
07
Biomarkers
CCR8 expression level in tumor-infiltrating Tregs
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