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Target intelligence / Profile preview
Chemokine receptor CCR5 (None)
- Target
- None
- Molecular classification
- G protein–coupled receptor, GPCR, Receptor
01
Overview
CCR5 is a G protein-coupled receptor that belongs to the chemokine receptor family. It is expressed on various immune cells, including T cells, macrophages, and dendritic cells, and plays a crucial role in immune cell trafficking and inflammation. CCR5 is also a co-receptor for HIV-1 entry into host cells, making it a significant therapeutic target for HIV infection. Additionally, it contributes to the pathogenesis of various inflammatory diseases and cancer metastasis.
- Other names
- CCR5CD195CC chemokine receptor type 5
02
Mechanism of action
Chemokine receptor antagonism; Inhibition of HIV entry; Inhibition of immune cell migration
03
Biological functions
Immune cell traffickingInflammationChemokine signalingLeukocyte recruitmentImmune response
04
Disease associations
HIV infectionRheumatoid arthritisMultiple sclerosisAsthmaCancerInflammatory diseases
05
Safety considerations
Potential for immunosuppressionIncreased risk of certain infectionsPossible neurological effects
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