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Target intelligence / Profile preview
Chemokine receptor CCR7 (CCR7)
- Target
- CCR7
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor
01
Overview
Chemokine receptor CCR7 is a G protein-coupled receptor that plays a central role in the immune system by guiding the migration of immune cells, particularly dendritic cells and lymphocytes, to secondary lymphoid organs. It is implicated in tumor metastasis and chronic inflammatory diseases, making it a promising therapeutic target.
- Other names
- C-C chemokine receptor type 7CD197
02
Mechanism of action
Modulation of CCR7 signaling pathways (PI3K/Akt, MAPK, RhoA); Inhibition of adenylate cyclase
03
Biological functions
Immune cell homingImmune cell migrationSignal transductionChemotaxisRegulation of cell survivalRegulation of actin dynamicsEndocytosis
04
Disease associations
Tumor metastasisChronic inflammationRheumatoid arthritisCancer
05
Safety considerations
Potential for off-target effects due to broad expression in immune cellsTherapeutic challenges in achieving selective targeting of CCR7 in specific cell types or tissues
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