Chemokine receptor on dendritic cell (specific examples: e.g., CCR7, XCR1)

Chemokine receptors on dendritic cells are a group of G protein-coupled receptors (GPCRs) expressed on the surface of dendritic cells that enable them to sense and respond to chemokine gradients. Major examples include CCR7, which mediates the migration of mature dendritic cells to lymph nodes in response to CCL19/CCL21, and XCR1, which is uniquely expressed on cross-presenting dendritic cells and guides them via XCL1 ligands[1][2][3][6]. These receptors regulate essential dendritic cell functions such as chemotaxis, adhesion, survival, and immune activation, and are key to spatial and temporal coordination of immune responses[1][3][5]. Dysregulation of their expression or function is implicated in immune disorders, infections, and cancer. Because they represent nodal points in immune cell trafficking and activation, individual chemokine receptors (but not the entire group generically) are considered therapeutic targets for modulating immunity, improving vaccine efficacy, and controlling autoimmunity or tumor responses[1][5]. Note: The provided entry is NOT a single protein/receptor but rather a heterogeneous group of receptors that should be considered and curated individually (e.g., CCR7, XCR1)[3]. Each has unique properties, ligands, and roles in dendritic cell biology. The name "Chemokine receptors on dendritic cells" is overly broad and not a canonical target; structured information should be captured for individual chemokine receptors where possible.

Other names

Chemokine GPCRs on dendritic cellsDC-chemokine receptorsChemokine receptors (on DC)includes specific receptors such as CCR7, XCR1, CCR5, CXCR4, etc.

Antagonism/inhibition of chemokine receptor signaling to block migration or activation Agonism to enhance dendritic cell migration or immune priming (research stage)