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Chemokine receptors are a family of G protein-coupled receptors that bind to chemokines, a class of chemotactic cytokines. These receptors play a crucial role in directing the migration of immune cells, including T cells, to sites of inflammation or infection. They are essential for immune surveillance, host defense, and tissue homeostasis. Different chemokine receptors are expressed on various immune cell subsets and mediate distinct signaling pathways, influencing cell trafficking, activation, and differentiation.
Antagonism of chemokine receptor signaling, inhibiting cell migration and recruitment.
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