Target intelligence / Profile preview

Chemokine Receptors (N/A)

Target
N/A
Molecular classification
G protein-coupled receptor
01

Overview

Chemokine receptors are a family of G protein-coupled receptors that bind to chemokines, a class of chemotactic cytokines. These receptors play a crucial role in directing the migration of immune cells, including T cells, to sites of inflammation or infection. They are essential for immune surveillance, host defense, and tissue homeostasis. Different chemokine receptors are expressed on various immune cell subsets and mediate distinct signaling pathways, influencing cell trafficking, activation, and differentiation.

Other names
Chemokine receptorsC-C chemokine receptorsC-X-C chemokine receptorsCXCRCCR
02

Mechanism of action

Antagonism of chemokine receptor signaling, inhibiting cell migration and recruitment.

03

Biological functions

Signal transductionCell migrationImmune responseT cell recruitment
04

Disease associations

InflammationInfectionCancerAutoimmunity
05

Safety considerations

ImmunosuppressionOpportunistic infectionsAltered immune responses
06

Interacting drugs

Maraviroc

1 more in the full profile.

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