Chikungunya virus envelope glycoprotein E1–E2 complex

The **Chikungunya virus envelope glycoprotein E1–E2 complex** is the principal surface protein complex of the Chikungunya virus (CHIKV), comprising two glycoproteins (E1 and E2) arranged as heterodimers that form spikes covering the viral envelope[1][5][9]. E2 is primarily responsible for binding to host cell receptors, while E1 mediates the fusion between viral and host endosomal membranes during entry; both are essential for viral infectivity[1][2][5][7]. The complex is a major focus of antiviral intervention, as it governs essential steps in viral attachment and entry, and it is the main target for neutralizing antibodies and entry inhibitors under development[2][6][8]. Mutations in E1 or E2 can affect receptor binding, cell tropism, and resistance to antiviral compounds, highlighting its pivotal role in CHIKV pathogenesis and as a major antiviral drug target[3][8].

Other names

CHIKV E1–E2 glycoprotein complexEnvelope protein E1/E2E1–E2 heterodimerChikungunya virus envelope proteins

Inhibitors bind to the E1–E2 interface or fusion loop, preventing membrane fusion and viral entry[2][4][6] Monoclonal antibodies block host cell receptor binding or prevent conformational changes needed for membrane fusion[8]